The global hype and attention to CBD make it convenient to forget that it is simply one among scores of cannabinoids. In reality, there are almost 110 known naturally occurring phyto-cannabinoids till date. Few of these molecules contain their individual healthful features, while others function similar to cannabidiol.
Moreover, whenever a product enumerates “full spectrum” in its composition, it’s an assurance that these different players will advance the therapeutic advantages of the concoction. So which are the “other” cannabinoids and why should we pay attention to them?
It’s not merely CBD that possesses healthful properties, though it is the most diverse of the plant compound. There are a host of other lesser known cannabinoids like cannabichromene (CBC), cannabinol (CBN), and the mother of all cannabinoids CBG.
Cannabigerol (CBG) – The Prolific Phytocannabinoid
Following CBD, the most productive classical phytocannabinoid comprises cannabigerol, also called CBG. As discovered by researchers, CBG is by itself a powerful appetite stimulant, neuroprotectant (particularly for Huntington’s disease), besides a therapy for IBS. Similar to CBD, CBG is considered “well tolerated” carrying least side effects. Additionally, CBG is non-psychoactive and does not make you high.
Scientists regard CBG as the “stem cell of cannabinoids” since it is the precursor to THC, CBD, CBC, and various minor compounds.
CBG And The ECS (Endocannabinoid System)
CBG, or cannabigerol, constitutes the forefront in cannabinoid research. Human possesses an endocannabinoid system controlling all body activities like sleep, digestion, and nerves. It comprises the body’s biggest receptor system and supports homeostasis. The two main types include CB1 and CB2.
Whereas the CB1 receptor attaches mainly with the brain and nervous mechanism, the CB2 receptor communicates with the immune system. The cannabinoid CBG relies on these receptors to create an array of possible health benefits and influences. Moreover, CBG communicates with the cannabinoid receptors CB1 plus CB2 and functions as a likely inhibitor to THC and its psychoactive effects.
CBG is also believed to augment the endocannabinoid anandamide that increments dopamine levels which control functions like mood swings, sleep cycles and appetite. GABA uptake inside the brain can be blocked by CBG, which renders this cannabinoid to become an anti-anxiety component and muscle soother. Besides, it can also obstruct serotonin receptors, which displays its antidepressant abilities.
What Constitutes IBS (IBS)
IBS, or IBS, comprises a lasting disorder that can lead to nasty and painful symptoms like abdominal pain, diarrhea, bloating (formation of gas or gaseous sensations within the stomach), besides constipation.
The primary cause and origin of IBS are unknown, and scientists are still analyzing different factors to identify the source of this ailment. Certain persons may be genetically inclined to IBS.
CBG’s Role In Irritable Bowel Syndrome (IBS)
Surprisingly, cannabidiol can control various physiological functions by the endocannabinoid mechanism. CBG’s main role in IBS includes its action as an agent for anti-swelling, which it achieves by balancing cytokine cascade. This efficiency as an agent for anti-swelling prompted researchers to examine CBG’s potential in healing irritable bowel syndrome.
It was observed that cannabinoids have the capacity to decrease gastrointestinal transport in rats by stimulating CB1, rather than CB2 receptors. Nevertheless, both CB1, as well as CB2 receptors, were discovered to lessen upswing of intestinal mobility resulting from the inflammatory response in clinical examinations at random examinations. Research upheld that the control of our endocannabinoid setup within the gut through cannabinoids like CBG can offer a valuable therapy for a gastrointestinal ailment like IBS.
In addition, the impact of CBG upon generation of nitric oxide and oxidative tension were analyzed utilizing rodent macrophages as well epithelial cells of the intestine The outcome revealed that CBG lessened murine colitis and decreases nitric oxide development in macrophages by stimulation through CB2 receptors.
Besides, CBG also weakened the creation of Reactive Oxygen Species (ROS) within epithelial cells of the intestine. Further clinical testing of CBG for Irritable Bowel Disease patients was recommended to decide whether it may be used as a therapeutic alternative.
CBG exhibits encourage trends in the medicinal benefits provided by cannabinoids. It may well emerge as among the most therapeutically used cannabinoids to provide multiple remedies like an antibacterial agent, an antioxidant, reducing inflammation, treating gastrointestinal disorders, combating cancer, and lessening intraocular pressure. And of late, it has also functioned like a therapeutic agent for treating IBS.
Interesting Read: CBD As An Antidepressant